Description
An aminouracil in which the ring hydrogens at positions 5 and 6 on uracil have been replaced by amino groups.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C4H6N4O2 | 0 | 142.116 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 5,6-diaminopyrimidine-2,4(1H,3H)-dione | C1(C(=C(NC(N1)=O)N)N)=O | InChI=1S/C4H6N4O2/c5-1-2(6)7-4(10)8-3(1)9/h5H2,(H4,6,7,8,9,10) | BBTNLADSUVOPPN-UHFFFAOYSA-N |
|
Citations
- Fraisse, L, et al. 1993. Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity. Journal of Medicinal Chemistry. 36(10).
- Jung, DK, et al. 2006. Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Proceedings of the National Academy of Sciences of the United States of America. 103(26).
- Raychaudhuri, A, et al. 2003. A familiar motif in a new context: the catalytic mechanism of hydroxyisourate hydrolase. Biochemistry. 42(22).
- Retailleau, P, et al. 2005. Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site. Acta Crystallographica. Section D, Biological Crystallography. 61(Pt 3).
- Yashio, K, et al. 2011. Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout. Bioorganic & Medicinal Chemistry Letters. 22(1).