Description
A 6-alkylaminopurine that is adenine where one of the hydrogens of the amino group is replaced by a hydroxymethyl group.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C6H7N5O | 0 | 165.153 |
Recommended notation
| Name | 6-hydroxymethyladenine |
|---|---|
| Abbreviation | 6hmA |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| (9H-purin-6-ylamino)methanol | C=1N=C(C=2N=CNC2N1)NCO | InChI=1S/C6H7N5O/c12-3-11-6-4-5(8-1-7-4)9-2-10-6/h1-2,12H,3H2,(H2,7,8,9,10,11) | KFYZVFUMYFTSNB-UHFFFAOYSA-N |
|
Nature
| Origin | Function | Functional detail |
Organisms
|
References |
|---|---|---|---|---|
| natural | epigenetic mark |
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Citations
- Fu, Y, et al. 2013. FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nature Communications. 4.
- O'Brown, ZK, et al. 2016. N6-Methyladenine: A Conserved and Dynamic DNA Mark. Advances in Experimental Medicine and Biology. 945.
- Xiong, J, et al. 2018. N 6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals. Nucleic Acids Research. 47(3).