DNAmod: 7-methylguanine

Description

A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.

Chemical properties

Chemical formula	Net charge	Average mass
C6H7N5O	0	165.153

Recommended notation

Name	7-methylguanine
Abbreviation	7mG

Nature

Origin	Function	Functional detail	Organisms	References
natural	damage	cytotoxic	Escherichia coli Homo sapiens Mesocricetus auratus Mus musculus Rattus norvegicus	Culp, LA, et al. 1970. Methylated bases in DNA of animal origin. Archives of Biochemistry and Biophysics. 136(1). Margison, GP, et al. 1976. Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine. The Biochemical Journal. 157(3). Frei, JV, et al. 1978. Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma Some applications of high-pressure liquid chromatography. The Biochemical Journal. 174(3). Faustman-Watts, EM, et al. 1984. DNA-purine methylation in hepatic chromatin following exposure to dimethylnitrosamine or methylnitrosourea. Biochemical Pharmacology. 33(4). Mielecki, D, et al. 2014. Ada response - a strategy for repair of alkylated DNA in bacteria. FEMS Microbiology Letters. 355(1).

Database references:

CHEBI:2274

Citations

Chao, MR, et al. 2005. Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with on-line solid-phase extraction. Rapid Communications in Mass Spectrometry : RCM. 19(17).
Culp, LA, et al. 1970. Methylated bases in DNA of animal origin. Archives of Biochemistry and Biophysics. 136(1).
Faustman-Watts, EM, et al. 1984. DNA-purine methylation in hepatic chromatin following exposure to dimethylnitrosamine or methylnitrosourea. Biochemical Pharmacology. 33(4).
Frei, JV, et al. 1978. Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography. The Biochemical Journal. 174(3).
Margison, GP, et al. 1976. Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine. The Biochemical Journal. 157(3).
Mielecki, D, et al. 2014. Ada response - a strategy for repair of alkylated DNA in bacteria. FEMS Microbiology Letters. 355(1).