Description
An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C8H11N5O3 | 0 | 225.20460 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one | Nc1nc2n(COCCO)cnc2c(=O)[nH]1 | InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) | MKUXAQIIEYXACX-UHFFFAOYSA-N |
|
Citations
- Keller, AN, et al. 2017. Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nature Immunology. 18(4).
- Metushi, IG, et al. 2015. Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity. PloS One. 10(5).
- Sampson, MR, et al. 2013. Population pharmacokinetics of intravenous acyclovir in preterm and term infants. The Pediatric Infectious Disease Journal. 33(1).
- Sipe, J, et al. 2001. Aciclovir for Bell's palsy (idiopathic facial paralysis). The Cochrane Database of Systematic Reviews. (4).
- Spangler, JG, et al. 1994. Uses and safety of acyclovir in pregnancy. The Journal of Family Practice. 38(2).
- Stanberry, LR, et al. 2002. Genital herpes simplex virus infection in the adolescent: special considerations for management. Paediatric Drugs. 4(5).