Description

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.

Chemical properties

Chemical formula Net charge Average mass
C8H12N5O4P 0 273.186
adefovir

Nomenclature

IUPAC SMILES InChI InChIKey Synonyms
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid N1(C2=C(C(N)=NC=N2)N=C1)CCOCP(O)(=O)O InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16) SUPKOOSCJHTBAH-UHFFFAOYSA-N
  • drg-0156
  • n-(2-phosphonylmethoxyethyl)adenine
  • hsdb 8079
  • pmea
  • 9-(2-(phosphonomethoxy)ethyl)adenine
  • gs 393
  • 9-(2-phosphonylmethoxyethyl)adenine
  • gs 0393
  • gs-0393