Description
An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C4H4FN3O | 0 | 129.09250 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 4-amino-5-fluoropyrimidin-2(1H)-one | Nc1nc(=O)[nH]cc1F | InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9) | XRECTZIEBJDKEO-UHFFFAOYSA-N |
|
Citations
- Abuhammour, W, et al. 2001. Systemic antifungal agents. Indian Journal of Pediatrics. 68(7).
- Einstein, H, et al. 1973. Flucytosine, a major antifungal agent. California Medicine. 119(5).
- Ellepola, AN, et al. 2015. In vitro postantifungal effect, adhesion traits and haemolysin production of Candida dubliniensis isolates following exposure to 5-fluorocytosine. Mycoses. 58(9).
- Fothergill, AW, et al. 2013. Comparison of MICs of fluconazole and flucytosine when dissolved in dimethyl sulfoxide or water. Journal of Clinical Microbiology. 51(6).
- Garcia, H, et al. 2015. Caspofungin irrigation through percutaneous calicostomy catheter combined with oral flucytosine to treat fluconazole-resistant symptomatic candiduria. Journal De Mycologie Medicale. 25(1).
- Keller, AN, et al. 2017. Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nature Immunology. 18(4).
- Markaki, M, et al. 2004. Insect population control using female specific pro-drug activation. Insect Biochemistry and Molecular Biology. 34(2).