Description
A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C10H13N5O5 | 0 | 283.24092 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| guanosine | Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O | InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1 | NYHBQMYGNKIUIF-UUOKFMHZSA-N |
|
Citations
- Chang, R, et al. 2008. Neuroprotective effects of guanosine on stroke models in vitro and in vivo. Neuroscience Letters. 431(2).
- Chessman, D, et al. 2008. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity. 28(6).
- Cohen, B, et al. 2004. Strickler-Berg analysis of excited singlet state dynamics in DNA and RNA nucleosides. Faraday Discussions. 127.
- Colburn, KK, et al. 2001. Circulating antibodies to guanosine in systemic lupus erythematosus: correlation with nephritis and polyserositis by acute and longitudinal analyses. Lupus. 10(6).
- D'Alimonte, I, et al. 2007. Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells. Journal of Immunology (Baltimore, Md. : 1950). 178(2).
- Dal-Cim, T, et al. 2011. Guanosine is neuroprotective against oxygen/glucose deprivation in hippocampal slices via large conductance Ca²+-activated K+ channels, phosphatidilinositol-3 kinase/protein kinase B pathway activation and glutamate uptake. Neuroscience. 183.
- Darlington, DN, et al. 2005. Purine nucleosides stimulate Na/K ATPase, and prolong survival in hemorrhagic shock. The Journal of Trauma. 58(5).
- Molz, S, et al. 2011. Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition. Journal of Neuroscience Research. 89(9).
- Munns, TW, et al. 1989. Antibody-nucleic acid complexes. Oligo(dG)n and -(dT)n specificities associated with anti-DNA antibodies from autoimmune MRL mice. Biochemistry. 28(26).
- Rathbone, MP, et al. 2011. Systemic administration of guanosine promotes functional and histological improvement following an ischemic stroke in rats. Brain Research. 1407.
- Sun, Y, et al. 2006. Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase. Antimicrobial Agents and Chemotherapy. 51(1).
- Volpini, R, et al. 2011. Evidence for the existence of a specific g protein-coupled receptor activated by guanosine. ChemMedChem. 6(6).
- Zhang, G, et al. 2011. Complete genome sequence of Bacillus amyloliquefaciens TA208, a strain for industrial production of guanosine and ribavirin. Journal of Bacteriology. 193(12).